|The Grape Seed – An Overview|
1535: OPC as remedy for the antioxidant deficiency disease scurvy.
Jacques Cartier, the French explorer, and his team had to spend a winter in Canada. As vitamin-rich food was missing, scurvy soon broke out. Help came from the Indians: with an infusion of bark and needles from the OPC-containing white cedar tree the team could be cured.
1947: Prof. Jack Masquelier, Bordeaux, first discovered oligomere proanthocyanadines (OPC), which he first extracted from peanut shells, and later from grape seeds. Today Masquelier is nominated as candidate for the Nobel Prize.
B. Basic Research , Analyses
Research by Prof. Jack Masquelier have shown that OPC from grape seeds has 18,4 times stronger effect against free radicals than Vitamin C.Source: Prof. Masquelier 1985
A Japanese research team found out that OPC had a 50 times stronger anti-oxydative effect than Vitamin E.Source: Uchida, Edamatsu et al.”Condensed tannins scavenge active oxygen free radicals”. In Med.Sci.Res. (15) (1987), page 8331f
No foodstuff contains nearly as a high concentration of OPC as grape seeds, and this includes the cold-pressed grape seed oil, but specifically the grape seed flour: approximately 20 mg/g – a gigantic amount for a natural product.Source: Research by Prof. Treutter, Centre of Sciences Weihenstephan, 2000.
On the occasion of the Second Science Congress, Forum Grape Seed, in Trittenheim, 2004 Prof. Elstner of the Centre of Sciences Weihenstephan, examined the anti-oxydative effect of OCP compared to isolated Vitamin E, apple juice and gallic acid. The result was a scientific sensation: in all test carried out diluted (!) grape seed flour was superior to isolated Vitamin E.Source: Erich Elstner: Simulated digestion of Vitis Vinafera Seed Powder: Polyphenolic Content and Antioxidant Properties. In: Journal of Agriculture and Food Chemistry 2006
“From the research results submitted at the II Forum Grape Seed it can be concluded that grape seed products are particularly suitable to counteract oxidative stress.”
Source: II. Forum Grape Seed, 16 September 2004 – Communiqué, signed by: Prof. Dr. rer. nat.Erich F. Elstner, Science Centre Weihenstephan (TUM), Freising; Winfrid Heinen, VITIS AG, Trittenheim; Dr. med. Michael Keck, Drei-Burgen-Klinik, Bad Münster am Stein; Prof. Dr. med. Bernd Krönig, Elisabeth-Krankenhaus, Trier; Dr. Bertrand Matthäus, Federal Research Institute for Nutrition and Foodstuffs, Mümster; Prof. Dr. Suhaila Mohamed, University Putra Malaysia, Prof. Dr. Dr. Kurt S. Zänker, University Witten/Herdecke
C. Nutrition Physiology
Research carried out by Prof. Masquelier in respect of bioavailability of OPC shows that :
· OPC has a nearly 100% bioavailability.
· It is water soluble and can be absorbed into the blood stream within a few minutes through the oral and gastric mucosa and is distributed within a short period of time into the various organs as well as to the entire body tissues, including skin, hair and nails.
· OPC reaches its maximum concentration in the blood after 45 minutes and is used up completely within 72 hours.
· It passes the haemato-encephalic- barrier (selection of utilizable substances) and can, therefore, be an effective protection of the brain cells.
· After 24 hours the resistance of the blood vessels has doubled.
· Long-term studies have proven that OPC is not toxic, carcinogenic or mutagenic.
Source: Schwitters, B., Masquelier, J: The fundamental tests. In: OPC in Practice. Rome/Italy, page 49 f
It follows that the supply with natural OPC via the daily food intake appears to be the best way. Besides, cold-pressed grape seeds can enhance meals with grape seed flour, e.g. grape seed noodles, grape seed bread and grape seed crackers….
“Therefore, supplementing with natural anti-oxydative polyunsaturated fatty acids, such as are present in grape seed oil and/or in the use of natural anti-oxydants (procyanidins) respectively, can be substantiated as additional improvement of healthy nutrition which can reduce cardiovascular risks in primary and secondary prevention.
Source: Dr. Michael Keck: Grape Seed Products as Add-On- Nutrition for Cardiovascular Patients. Drei-Burgen-Klinik, Bad Münster am Stein.
Study “Grape-Seed Products as Add-on Nutrition for Cardiovascular Patients: with 10 test persons:Study Group: LDL-Cholesterol lowered from 125 mg/gl to 93 mg/dl (Control group: 124 mg/dl to 109 mg/dl); HDL-Cholesterol increased from 41 mg/dl to 54 mg/dl (Control group: 42 mg/dl to 45 mg/dl).Source: Dr. Michael Keck: Grape seed products as Add-on-nutrition for cardiovascular patients, Drei-Burgen-Clinic, Bad Münster am Stein
OPC from Grape Seed improves tolerance to chemotherapySource: Dr. med. Arnold Zilly, Heidelberg, 2006
“According to a minor study extract from grape seeds lowers blood pressure and – in higher dosage – also improves the blood lipids”Source: Medical Tribune No. 16, 21.04.2006
OPC “A type of substance, which has lately gained attention due to the health-promoting properties (anti-inflammatory/anti-atherosclerotic, anti-mutagenic, anti-allergic…)Source: Dr. Herbert Böchzelt, Joanneum Research, Austria Compare also: Shi J., Yu J; Pohorly JE; Kakuda Y: “Polyphenolics in grape seeds-biochemistry and functionality” Journal of medicinal food VOL: 6(4); p. 291-9/2003 Winter
OPC inhibits growth of breast cancerSource: Ramljak D and others: Pentameric procyanidines from Theobroma cacao selectively inhibits growth of human breast cancer cells”.. Georgetown University Medical Center, Washington, USA.
OPC as protection for the blood supply of myocardiumSource: ZAng, XH and others: “Protective effect of procyanidins from the seedpod of the lotus on myocardial ischemia and reperfusion injury in rat”, University of Science and Technology, Wuhan, China.
C is suitable for therapy if venous diseases
Source: Constantini, A. and others: “Clinical and capillaroscopic evaluation of chronic uncomplicated venous insufficiency with procyanidins extracted from vitis vinifera”, Universita degli Studi, Milano, Italy
Wellness / Skin care
Grape Seed Oil as Skin Oil: “In all patients the oil was able to alleviate pruritus and to considerably improve scaly and chapped skin. […] Applying the oil on minor lesions also benefited healing.”
Source: Dr. med. Peter Schachinger, Celle: Monitoring the application in 29 patients, 2001
NATURE AND ENJOYMENT
Already in the Middle Ages well-to-do ladies used cold-pressed grape seed oil as cosmetic, as it was known that this oil keeps the skin healthy, vital and subtle, as well as beautiful. Even today pharmacists use cold-pressed grape seed oil as basis for ointments and creams prescribed by dermatologists, and recently cold-pressed grape seed oil has been rediscovered for use in luxury cosmetic.Source: VWinfrid Heinen:”Power from the grape seed”. Kilianverlag, 2003
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