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1.   BBC NEWS | Health | Grapes 'may prevent cancer scarring'

Grapes could help women to avoid the painful scarring often associated ... Professor John Yarnold and colleagues at the Institute of Cancer ...

SOURCE: Cancer Research UK (http://www.cancerresearchuk.org)

Grapes 'may prevent cancer scarring'

 

Grapes contain powerful antioxidants

Grapes could help women to avoid the painful scarring often associated with breast cancer treatment.

Doctors at The Institute of Cancer Research in London believe the antioxidants in grapes may protect against radiation fibrosis.

This condition affects thousands of women around the world each year. It causes tissue around the breast to become hard and stiff. In some cases, it is painful.

I believe grape seed extract has interesting potential


Professor John Yarnold,
Institute of Cancer Research

This scarring can occur years after the women undergo radiotherapy to treat breast cancer.

In recent years, advances in radiotherapy treatment have meant that the likelihood of women developing radiation fibrosis has fallen.

However, it can still occur and doctors cannot offer women guarantees that they will not have any scarring.

Cell damage

While doctors do not know what causes radiation fibrosis, they suspect it may be caused by the continuous release of free radicals triggered by radiotherapy.

Free radicals spread like a kind of biological rust and can cause havoc in cells, even damaging DNA.

Antioxidants can mop up these potentially damaging molecules.

Professor John Yarnold and colleagues at the Institute of Cancer Research are now looking to see if the antioxidant properties in grapes could have a role to play.

"Grape seeds contain a mixture of compounds called flavanoids, also found in other fruits and vegetables," said Professor Yarnold.

"They have antioxidant properties that may be superior to known antioxidants like vitamin E or C.

"There have already been promising small scale trials with antioxidants, but I believe grape seed extract has interesting potential."

Tissue hardening

The doctors are planning to recruit 72 patients initially. Half will be given tablets containing grape seed extract while the others will receive a dummy pill.

This will enable the researchers to determine if the grape seed extract can protect women from fibrosis.

Professor Yarnold said: "Radiotherapy is followed over the years by tissue hardening and tenderness in the breast and underlying muscles in some women.

"We aim to test if grape seed extract reverses these changes and improves patients' quality of life."

He added: "If successful, we aim to conduct further clinical trials in radiotherapy patients cured of other cancers where fibrosis may cause other serious medical problems."

Sir Paul Nurse, chief executive of Cancer Research UK which is funding the study, said: "We hope this trial will eventually lead to a treatment for patients who previously had no respite from the symptoms of radiation fibrosis."

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Diabetes Print E-mail
Written by Omid   
Thursday, 06 March 2008

           

 Diabetes-Clinical Trials

Cold Pressed Grape Seed Oil & Grape Seed Meal

Prof. Dr. Peter Eckart, Auf dem Heidgen 29, 53127 Bonn, Germany

Cold –pressed grape seed meal/oil contains high concentrations of cyclical polyphenols and other agents like: flavine 3-gallate, flavine-3’-gallate, flavin-3, 3’-gallate and epica techol-3-gallate, of the EGCG and the epigallocatechol, ECG.

It is known that these agents influence the tyrosine kinasis receptor in biochemical experiments. The protein tyrosine-kinases regulate the cell proliferation, the cell differentiation and, at the same time, serve as signaler for further intra-cellular functions.

 

LifeExtension

·        Scientific Abstracts: Le Magazine, July 2005- Abstracts: Mediterranean Diet, Adhd, Seed Extract, Diabetes, And Fibromyalgia.

·        Intracellular mediators of procyanidin-induced lipolysis in 3T3-L1 adipocytes.

·        Grape seed proanthocyanidins extract promotes bone formation in rat’s mandibular condyle.   

 

 

Compound Identified In Grape May Fight Cancer And Diabetes

ScienceDaily (May 22, 2002)_Researchers with the U.S. Department of Agriculture have identified another compound in grapes that they believe shows promise in fighting cancer.

The compound, pterostilbene, is similar to resveratrol, an antioxidant recently found in grapes and red wine that has also been linked to cancer-prevention, they say.

Previous studies by others have demonstrated that pterostilbene also has antidiabetic properties. The current study is the first to identify it as a cancer-preventive agent, the researchers report. Their study is tentatively scheduled to appear in the June 19 issue of the Journal of Agricultural and Food Chemistry, a peer-reviewed publication of the American Chemical Society, the world’s largest scientific society. It was published on the Web version of the journal on May 10.

 

 

 

Grape Seed-Derived Procyanidins Have an Antihyperglycemic Effect in Streptozotocin-Induced Diabetic Rats and Insulinomimetic Activity in Insulin-Sensitive Cell Lines

 

Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43005 Tarragona, Spain

Last Updated ( Sunday, 23 March 2008 )
 
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